海外临床试验导航

结直肠癌

帮助用户按结肠癌、直肠癌、MSI/MMR、RAS、BRAF、HER2 等方向检索海外公开临床试验。

中文医学标准名
结肠癌和直肠癌
英文医学标准名
Colorectal Cancer
试验数据最后同步
2026-07-10

Synced trials

当前同步到的治疗类试验

以下记录来自公开临床试验数据库,已按招募状态、治疗目的、干预类型和癌症相关性做初步过滤。本站不判断患者是否符合入组条件,请以官方页面、医生和研究团队意见为准。

最后同步日期:2026-07-10 · 当前显示 539 条

招募状态和入组条件可能随时变化。请以官方页面、医院和研究机构信息为准,并带给主治医生或肿瘤科医生讨论。

状态
全部
试验阶段
全部
治疗类型
全部
国家/地区
全部
正在招募 Phase 2 药物
clinicaltrials.gov NCT07085169

Low-dose Trifluridine/Tipiracil With Bevacizumab in mCRC

适用疾病
Colo-rectal Cancer;Third-line and Beyond Therapy;TAS 102
干预
Trifluridine/tipiracil (TAS-102) plus bevacizumab
地点
China
申办方
Ruijin Hospital
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT06910657

IDOV-Immune for Advanced Solid Tumors

适用疾病
Colorectal Cancer;Pancreatic Cancer;Melanoma
干预
IDOV-Immune (oncolytic vaccinia virus)
地点
United States,Australia
申办方
ViroMissile, Inc.
即将招募 Phase 2 药物
clinicaltrials.gov NCT07337551

Gossypol Acetate + FOLFIRI + Bev in mCRC With TP53-Mutant and LRPPRC Positive

适用疾病
Patients With Metastatic Colorectal Cancer Who Were TP53-mutant and LRPPRC-positive and Had Previously Failed Prior First-line Treatment
干预
Gossypol acetate Combined with Bevacizumab and FOLFIRI
地点
未列出
申办方
Guiying Wang
正在招募 Phase 1, Phase 2 生物制剂药物
clinicaltrials.gov NCT07079631

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

适用疾病
Metastatic Colorectal Cancer
干预
BNT314,Pumitamig,SoC chemotherapy treatment 1,SoC chemotherapy treatment 2
地点
United States,Germany,Japan,Spain 等 1 个
申办方
BioNTech SE
正在招募 Phase 3 生物制剂药物
clinicaltrials.gov NCT06662786

A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

适用疾病
Colorectal Neoplasms
干预
Amivantamab,Cetuximab,5-fluorouracil,Leucovorin calcium/Levoleucovorin
地点
United States,Belgium,Brazil,Canada 等 18 个
申办方
Janssen Research & Development, LLC
正在招募 Phase 1 药物
clinicaltrials.gov NCT06867822

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

适用疾病
Advanced Colorectal Cancer;Metastatic Colorectal Cancer
干预
ProAgio,FOLFIRI,Bevacizumab
地点
United States
申办方
University of Alabama at Birmingham
正在招募 Phase 1, Phase 2 生物制剂
clinicaltrials.gov NCT07341737

SL-28 for Advanced Solid Tumours

适用疾病
Head & Neck Cancer;Pancreas Carcinoma;Pancreas Cancer, Metastatic
干预
SL-28,SL-28,SL-28
地点
Australia
申办方
Second Life Therapeutics
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT06324357

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

适用疾病
Metastatic Breast Cancer;Metastatic Gastric Adenocarcinoma;Gastroesophageal Junction Adenocarcinoma
干预
Zongertinib,Trastuzumab deruxtecan,Trastuzumab emtansine,Trastuzumab
地点
United States,Belgium,China,France 等 6 个
申办方
Boehringer Ingelheim
正在招募 Phase 1, Phase 2 生物制剂药物手术/操作
clinicaltrials.gov NCT07147231

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

适用疾病
Metastatic Colorectal Adenocarcinoma;Refractory Colorectal Adenocarcinoma;Stage III Colorectal Cancer AJCC v8
干预
Biopsy Procedure,Biospecimen Collection,Cemiplimab,Computed Tomography
地点
United States
申办方
National Cancer Institute (NCI)
即将招募 Phase 1 药物
clinicaltrials.gov NCT07658196

TLR9 Immunotherapy for Peritoneal Carcinomatosis

适用疾病
Malignant Ascites;Colorectal Adenocarcinoma;Peritoneal (Metastatic) Cancer
干预
ACM-CpG
地点
United States
申办方
Brown University
即将招募 Phase 2 药物
clinicaltrials.gov NCT07175636

QL1706 With Short-Course Radiotherapy and Chemotherapy for MSS Rectal Cancer

适用疾病
Locally Advanced Rectal Cancer (LARC);Mismatch Repair-Proficient (pMMR) Rectal Cancer;Non-metastatic Rectal Cancer
干预
Drug: QL1706 Drug: mFOLFOX6 Radiation: Short-Course Radiotherapy (SCRT)
地点
未列出
申办方
Sun Yat-sen University
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT06242470

A Study of MGC026 in Participants With Advanced Solid Tumors

适用疾病
Advanced Solid Tumor;Advanced Cancer;Metastatic Cancer
干预
MGC026 Dose Escalation,MGC026 Dose for Expansion
地点
United States,Australia,United Kingdom
申办方
MacroGenics
正在招募 Phase 1, Phase 2 联合产品药物
clinicaltrials.gov NCT03526835

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

适用疾病
Advanced/Metastatic Solid Tumors;Colorectal Cancer;Gastric Cancer
干预
MCLA-158,MCLA-158 + Pembrolizumab,MCLA-158 + FOLFIRI,MCLA-158 + FOLFOX
地点
United States,Belgium,France,Netherlands 等 2 个
申办方
Merus B.V.
正在招募 Phase 1 药物
clinicaltrials.gov NCT07020117

A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

适用疾病
Urothelial Carcinoma Bladder;Triple Negative Breast Cancer (TNBC);Hormone Receptor Positive Breast Adenocarcinoma
干预
[225Ac]Ac-AKY-1189 (therapeutic),[64Cu]Cu-AKY-1189 (imaging)
地点
United States
申办方
Aktis Oncology, Inc.
正在招募 Phase 1 药物
clinicaltrials.gov NCT06625775

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

适用疾病
Solid Tumor, Adult;Metastatic Breast Cancer;Advanced Breast Cancer
干预
BBO-10203,Trastuzumab,Fulvestrant,Ribociclib
地点
United States,Australia,Brazil,France 等 1 个
申办方
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
正在招募 Phase 2 药物
clinicaltrials.gov NCT06411600

Combination Therapy for BRAF-V600E Metastatic CRCm

适用疾病
Metastatic Colorectal Cancer
干预
Encorafenib,Cetuximab,Bevacizumab
地点
Spain
申办方
Vall d'Hebron Institute of Oncology
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT05186116

LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis

适用疾病
Colon Adenocarcinoma;Liver Metastasis Colon Cancer
干预
Living donor liver transplant, Split liver transplant, RAPID, DDLT
地点
Italy
申办方
Azienda Ospedaliero-Universitaria di Modena
即将招募 Phase 1, Phase 2 生物制剂
clinicaltrials.gov NCT07551778

Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid Tumors

适用疾病
NSCLC (Advanced Non-small Cell Lung Cancer);Colorectal Cancer;Advanced Solid Tumors
干预
NK Cells,NK cells + PD-(L)1 inhibitor + pemetrexed as first-line maintenance therapy,NK cells + cetuximab/bevacizumab + capecitabine as first-line maintenance therapy
地点
未列出
申办方
BOE Technology Group Co., Ltd.
正在招募 Phase 1 生物制剂药物手术/操作
clinicaltrials.gov NCT06696768

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

适用疾病
Metastatic Colorectal Adenocarcinoma;Stage III Colorectal Cancer AJCC v8;Stage IV Colorectal Cancer AJCC v8
干预
Bevacizumab,Biopsy Procedure,Biospecimen Collection,Computed Tomography
地点
United States
申办方
National Cancer Institute (NCI)
即将招募 Phase 1 生物制剂药物手术/操作
clinicaltrials.gov NCT07363408

Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer

适用疾病
Advanced Microsatellite Stable Colorectal Carcinoma;Metastatic Microsatellite Stable Colorectal Carcinoma;Stage III Colorectal Cancer AJCC v8
干预
Biospecimen Collection,Computed Tomography,Fluorouracil,Irinotecan
地点
United States
申办方
City of Hope Medical Center
正在招募 Phase 2, Phase 3 药物
clinicaltrials.gov NCT06243393

Sacituzumab Govitecan in Metastatic Colorectal Cancer

适用疾病
Metastatic Colorectal Cancer
干预
Sacituzumab Govitecan (SG),Physicians Choice (PhC).
地点
Germany
申办方
University Hospital Heidelberg
正在招募 Phase 2 药物
clinicaltrials.gov NCT06607458

Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

适用疾病
Refractory Metastatic Colorectal Cancer
干预
Melphalan/HDS Followed by Consolidation Treatment with Trifluridine-tipiracil plus Bevacizumab,Trifluridine-tipiracil plus Bevacizumab Alone
地点
United States,Czechia,Germany,Italy 等 4 个
申办方
Delcath Systems Inc.
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT04959604

Lymph Node Mapping Via Flourescent Dye in Colon Cancer

适用疾病
Colon Carcinoma;Lymph Node Metastases
干预
ICG-marking endoscopically
地点
Germany
申办方
Universitätsklinikum Hamburg-Eppendorf
正在招募 Phase 2 生物制剂
clinicaltrials.gov NCT06522919

Sequential Immunochemotherapy Treatment with Pembrolizumab Plus Dendritic Cell (DC) Vaccine Followed by Trifluridine/Tipiracil Plus Bevacizumab in Refractory Mismatch-repair-proficient (pMMR) or Microsatellite-stable (MSS) Metastatic Colorectal Cancer

适用疾病
Colorectal Cancer Metastatic;Microsatellite Stable Colorectal Carcinoma;Refractory Mismatch-repair-proficient (pMMR) Metastatic Colorectal Cancer
干预
Autologous Dendritic Cell (DC) Vaccine
地点
Italy
申办方
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
正在招募 Phase 2, Phase 3 药物
clinicaltrials.gov NCT07221357

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

适用疾病
Untreated, Unresectable, or Metastatic Colorectal Cancer
干预
Pumitamig,FOLFOX,FOLFIRI,Bevacizumab
地点
United States,Argentina,Australia,Austria 等 23 个
申办方
Bristol-Myers Squibb
正在招募 Phase 1 药物手术/操作
clinicaltrials.gov NCT06654037

Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

适用疾病
Metastatic Microsatellite Stable Colorectal Carcinoma;Refractory Microsatellite Stable Colorectal Carcinoma;Stage IV Colorectal Cancer AJCC v8
干预
Abemaciclib,Biopsy Procedure,Biospecimen Collection,Fluorouracil
地点
United States
申办方
National Cancer Institute (NCI)
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT01479608

Liver Transplantation and Colorectal Cancer

适用疾病
Colorectal Cancer;Liver Metastasis
干预
Liver transplantation and liver resection
地点
Norway
申办方
Oslo University Hospital
正在招募 Phase 2 器械药物
clinicaltrials.gov NCT05286814

PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma

适用疾病
Metastatic Colorectal Cancer (Mcrc);Intrahepatic Cholangiocarcinoma (Icc);Intrahepatic Bile Duct Cancer
干预
Dexamethasone,PDS01ADC,Intera 3000 Hepatic Artery Infusion Pump (HAIP),Floxuridine
地点
United States
申办方
National Cancer Institute (NCI)
正在招募 Phase 1 药物
clinicaltrials.gov NCT04999761

AB122 Platform Study

适用疾病
Advanced or Metastatic Solid Tumor;Pancreatic Ductal Adenocarcinoma;Colorectal Cancer
干预
AB122,AB122,TAS-116,AB122
地点
Japan
申办方
Taiho Pharmaceutical Co., Ltd.
即将招募 Phase 2 药物放疗
clinicaltrials.gov NCT06788171

PULSAR Combined With PD-1 Ab and Chemotherapy Plus Bev. for CRLM

适用疾病
Colorectal Cancer Liver Metastasis
干预
Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy,Bevacizumab,Capecitabine,Oxaliplatin
地点
China
申办方
Fujian Cancer Hospital
正在招募 Phase 1 药物
clinicaltrials.gov NCT05107674

A Study of NX-1607 in Adults With Advanced Malignancies

适用疾病
Ovarian Cancer, Epithelial;Gastric Cancer;GastroEsophageal Junction (GEJ) Cancer
干预
NX-1607,Paclitaxel
地点
United States,United Kingdom
申办方
Nurix Therapeutics, Inc.
正在招募 阶段未标明 药物其他手术/操作
clinicaltrials.gov NCT06449937

Local Liver Treatment for Multi-organ Colorectal Cancer Metastases

适用疾病
Metastatic Colorectal Carcinoma;Multi-organ Metastatic Colorectal Cancer;Metastatic Malignant Neoplasm in the Liver
干预
Radical local Surgery,Systemic therapy,Interventional therapy
地点
China
申办方
Anhui Provincial Hospital
正在招募 Phase 2 联合产品
clinicaltrials.gov NCT06889610

A Phase II Clinical Study of Multimodal Ablation Combined With Systemic Drug Therapy for Advanced Solid Tumors.

适用疾病
Triple Negative Breast Cancer Metastatic;Melanoma Metastatic;Colorectal Cancer Metastatic
干预
MTT(Multimodal Tumor Thermal Therapy System)- Colorectal Cancer,MTT(Multimodal Tumor Thermal Therapy System)- Triple-Negative Breast Cancer,MTT(Multimodal Tumor Thermal Therapy System)- Melanoma
地点
China
申办方
Fudan University
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT07194616

Rectal Cancer CTC Trial

适用疾病
Rectal Cancer Patients
干预
Primary Surgery,Neoadjuvant radiochemotherapy and surgery
地点
Czechia
申办方
University Hospital Ostrava
正在招募 Phase 3 药物手术/操作
clinicaltrials.gov NCT05815082

ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer

适用疾病
Colorectal Cancer;Liver Metastases;Circulating Tumor Cell
干预
Colorectal cancer resection combined with liver metastasis resection.,FOLFOX chemotherapy regimen
地点
China
申办方
Sixth Affiliated Hospital, Sun Yat-sen University
即将招募 Phase 2 药物
clinicaltrials.gov NCT07550088

BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases

适用疾病
Colorectal Cancer Metastatic
干预
Balstilimab (BAL),Botensilimab (BOT),agenT-797
地点
United States
申办方
Darren Sigal, MD
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05786924

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

适用疾病
Non-small Cell Lung Cancer;Histiocytic Neoplasm;Histiocytosis
干预
S241656,FOLFOX6/FOLFOX7,FOLFIRI,Cetuximab
地点
United States,Denmark,Hong Kong,Japan 等 1 个
申办方
Institut de Recherches Internationales Servier
正在招募 EARLY / Phase 1 生物制剂
clinicaltrials.gov NCT06937567

CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors

适用疾病
Biliary Tract Cancer;Colorectal Carcinoma;Gastric Cancer, Metastatic
干预
CDH17 CAR-T,FAST LACO-Stim CDH17 CAR-T
地点
China
申办方
Zhejiang University
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05086692

A Beta-only IL-2 ImmunoTherapY Study

适用疾病
Advanced Solid Tumor;Unresectable Solid Tumor;Clear Cell Renal Cell Carcinoma
干预
MDNA11,Pembrolizumab (KEYTRUDA®)
地点
United States,Australia,Canada,Ireland 等 3 个
申办方
Medicenna Therapeutics, Inc.
正在招募 Phase 3 药物其他
clinicaltrials.gov NCT05861505

COLLISION RELAPSE Trial

适用疾病
Colorectal Cancer;Liver Metastases;Liver Metastasis Colon Cancer
干预
Neoadjuvant systemic therapy (CAPOX+/-B FOLFOX+/-B FOLFIRI+/-B),Repeat local treatment
地点
Netherlands
申办方
Amsterdam UMC, location VUmc
正在招募 EARLY / Phase 1 药物放疗
clinicaltrials.gov NCT07128355

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

适用疾病
Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis
干预
Stereotactic Body Radiation Therapy (SBRT),Botensilimab,Balstilimab
地点
United States
申办方
Massachusetts General Hospital
即将招募 阶段未标明 放疗
clinicaltrials.gov NCT06053996

Hepatopulmonary Radio-sterilization With Immunotherapy

适用疾病
Colon Cancer;Liver Metastasis Colon Cancer;Rectal Cancer
干预
Hepatopulmonary radio-sterilization
地点
Israel
申办方
Sheba Medical Center
正在招募 Phase 1 药物
clinicaltrials.gov NCT06917079

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

适用疾病
Non-Small Cell Lung Cancer;NSCLC;PDAC - Pancreatic Ductal Adenocarcinoma
干预
BBO-11818,Pembrolizumab,Platinum chemotherapy (cisplatin or carboplatin),Pemetrexed
地点
United States,Australia
申办方
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
即将招募 Phase 1 生物制剂
clinicaltrials.gov NCT07587827

Study Evaluating the Safety Feasibility and Efficacy of ODI-2001 Vaccine, a Personnalized Immunotherapy in Patients With Metastatic or Locally Advanced Colon Cancer or Pancreatic Cancer

适用疾病
Metastatic Colorectal Cancer (CRC);Locally Advanced Colorectal Cancer;Metastatic Pancreatic Cancer
干预
Personalized cancer vaccine including : DNA neoantigen vaccine, MVA viral vector and Ipilimumab (anti-CTLA4)
地点
France
申办方
Centre Georges Francois Leclerc
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT07148128

Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of WEF-001 as Monotherapy in Advanced KRAS-Mutant Solid Tumours.

适用疾病
Advanced or Metastatic KRAS-mutant Tumor in Pancreatic Adenocarcinoma;Advanced or Metastatic KRAS-mutant Tumor in Colorectal Cancer;Advanced or Metastatic KRAS-mutant Tumor in Non Small Cell Lung Cancer
干预
WEF-001
地点
United States,Canada,United Kingdom
申办方
Auricula Biosciences Inc.
正在招募 Phase 2 药物
clinicaltrials.gov NCT05870800

Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER

适用疾病
Stage I Colon Cancer;Stage II Colon Cancer;Stage III Colon Cancer
干预
Tecentriq 1200 MG in 20 ML Injection + Capecitabine 1000 mg/m2 + Oxaliplatin 130 mg/m2,Oxaliplatin injection 85mg/m2 + Leucovorin 400mg/m2 + 5-Fluorouracil 2400mg/m2,Oxaliplatin 130mg/m2 + Capecitabine 1000mg/m2
地点
United States
申办方
Baylor College of Medicine
即将招募 Phase 1, Phase 2 生物制剂药物
clinicaltrials.gov NCT07591597

A Multicenter, Phase Ib/II Clinical Trial to Evaluate the Efficacy and Safety of Concurrent Combination Therapy of S-531011 Plus Fruquintinib or S-531011 Plus Fruquintinib Plus Pembrolizumab in Patients With MSS/pMMR Colorectal Cancer

适用疾病
Metastatic Colorectal Neoplasms;Microsatellite Stable / Proficient Mismatch Repair Colorectal Cancer
干预
S-531011,Fruquintinib,Pembrolizumab
地点
未列出
申办方
National Cancer Center Hospital East
正在招募 Phase 1 药物
clinicaltrials.gov NCT07348211

First in Human Study of SIM0610 in Solid Tumors

适用疾病
Advanced Solid Tumours;Non-Small Cell Lung Cancer;Colorectal Cancer
干预
SIM0610 for Injection,SIM0610 for Injection
地点
China
申办方
Jiangsu Simcere Pharmaceutical Co., Ltd.
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05824975

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

适用疾病
Advanced Solid Tumor;Metastatic Solid Tumor;Soft Tissue Sarcoma (STS)
干预
GI-102 subcutaneous (SC),GI-102,doxorubicin,paclitaxel
地点
United States,South Korea
申办方
GI Innovation, Inc.
即将招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT06484153

Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Advanced or Metastatic pMMR/MSS Colorectal Carcinoma

适用疾病
To Evaluate the Efficacy of Fruquintinib and Pirfenidone in Combination With Anti-PD-1 Antibody in Colorectal Carcinoma;To Evaluate Whether Pirfenidone Can Reshape the Tumor Microenvironment in Colorectal Cancer;Combination of Fruquintinib and Anti-PD-1 Antibody Was Reported to Improve Patient Prognosis in Colorectal Cancer
干预
Pirfenidone,Fruquintinib,Pembrolizumab
地点
未列出
申办方
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
即将招募 Phase 2 生物制剂药物
clinicaltrials.gov NCT07662031

Tovecimig Plus FOLFIRI in Second Line Metastatic Colorectal Cancer

适用疾病
Colorectal Cancer;Metastatic Colorectal Cancer
干预
Tovecimig,Irinotecan,Leucovorin,5-Fluorouracil (5-FU)
地点
United States
申办方
Washington University School of Medicine
正在招募 Phase 3 生物制剂药物手术/操作
clinicaltrials.gov NCT05863195

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

适用疾病
Metastatic Colorectal Carcinoma;Metastatic Malignant Neoplasm in the Liver;Stage IV Colorectal Cancer AJCC v8
干预
Bevacizumab,Cetuximab,Computed Tomography,Floxuridine
地点
United States
申办方
ECOG-ACRIN Cancer Research Group
即将招募 Phase 1, Phase 2 生物制剂药物
clinicaltrials.gov NCT07260058

Immune Cell Therapy for Advanced Solid Tumors

适用疾病
Lung Cancer (Locally Advanced or Metastatic);Liver Cancer (Locally Advanced or Metastatic);Colorectal Cancer (Locally Advanced or Metastatic)
干预
Autologous immune Cells,Standard chemotherapy
地点
未列出
申办方
Liaoning Medical Diagnosis and Treatment Technology Research and Development Co., Ltd.
正在招募 Phase 2 药物
clinicaltrials.gov NCT06820463

A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

适用疾病
Metastatic Colorectal Cancer
干预
Telisotuzumab Adizutecan,Fluorouracil,Oxaliplatin,Leucovorin
地点
United States,Australia,Austria,Brazil 等 9 个
申办方
AbbVie
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05919264

FOG-001 in Locally Advanced or Metastatic Solid Tumors

适用疾病
Cancer;Colorectal Cancer;Solid Tumor
干预
FOG-001,mFOLFOX-6,Nivolumab,Trifluridine/tipiracil
地点
United States,Australia
申办方
Parabilis Medicines, Inc.
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT07262619

EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors

适用疾病
Advanced Solid Tumors;MSI-H or dMMR Advanced Solid Tumors;MSI-H/dMMR Gastric Cancer
干预
EIK1005,pembrolizumab (KEYTRUDA® )
地点
United States,Australia,New Zealand
申办方
Eikon Therapeutics
正在招募 Phase 2 药物
clinicaltrials.gov NCT04701476

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

适用疾病
Colorectal Cancer; Lung Cancer
干预
TATE and pembrolizumab,TAS-102 pill,Regorafenib Pill
地点
United States,Taiwan
申办方
Teclison Ltd.
正在招募 Phase 1, Phase 2 药物手术/操作
clinicaltrials.gov NCT05691491

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

适用疾病
Advanced Malignant Solid Neoplasm;Advanced Microsatellite Stable Colorectal Carcinoma;Hematopoietic and Lymphatic System Neoplasm
干预
Biopsy Procedure,Biospecimen Collection,Computed Tomography,Magnetic Resonance Imaging
地点
United States
申办方
National Cancer Institute (NCI)
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05706129

A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors

适用疾病
Clear Cell Renal Cell Cancer (ccRCC);Pancreatic Ductal Adenocarcinoma (PDAC);Colorectal Cancer (CRC)
干预
[68Ga]Ga-DPI-4452,[177Lu]Lu-DPI-4452
地点
Australia,France
申办方
ITM Oncologics GmbH
即将招募 Phase 2 药物
clinicaltrials.gov NCT06972498

A Prospective Multicenter Study: Ivosimab + Chemotherapy as Neoadjuvant for Resectable pMMR/MSS CRC Liver Mets

适用疾病
Colorectal Cancer With Liver Metastasis
干预
Patients will receive ivosimab combined with the XELOX/FOLFOX regimen, followed by radical surgery 4-6 weeks after the last dose; adjuvant chemotherapy will continue for 3 months postoperatively.
地点
未列出
申办方
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
正在招募 Phase 1 药物
clinicaltrials.gov NCT04511039

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

适用疾病
Advanced Malignant Solid Neoplasm;Clinical Stage III Gastroesophageal Junction Adenocarcinoma;Clinical Stage IV Gastroesophageal Junction Adenocarcinoma
干预
Trifluridine and Tipiracil Hydrochloride,Talazoparib Tosylate
地点
United States
申办方
Roswell Park Cancer Institute
正在招募 Phase 2 药物
clinicaltrials.gov NCT07314294

Phase II Study of EMB-01 in Recurrent/Metastatic Colorectal Cancer Patients

适用疾病
Metastatic Colorectal Cancer
干预
EMB-01 1600 mg administered once weekly throughout the study,EMB-01 1600 mg once weekly for 6 weeks, then every 2 weeks thereafter
地点
China
申办方
Shanghai EpimAb Biotherapeutics Co., Ltd.
正在招募 Phase 2 药物
clinicaltrials.gov NCT06002789

Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC

适用疾病
Multiple Cancer;Colorectal Cancer
干预
MSI-H/MSS (dMMR/pMMR) mixed sMPCC: combination of mFOLFOX6+PD-1 monoclonal antibody neoadjuvant therapy,All-MSI-H (dMMR) sMPCC: single-drug PD-1 monoclonal antibody neoadjuvant therapy
地点
China
申办方
Sixth Affiliated Hospital, Sun Yat-sen University
正在招募 Phase 2 药物
clinicaltrials.gov NCT06529523

Tislelizumab in People With Colorectal Cancer

适用疾病
Colorectal Cancer
干预
Tislelizumab
地点
United States,Nigeria
申办方
Memorial Sloan Kettering Cancer Center
正在招募 Phase 2 药物
clinicaltrials.gov NCT03926338

Neoadjuvant Toripalimab With or Without Celecoxib in dMMR/MSI-H Colorectal Cancer

适用疾病
Colorectal Cancer;Mismatch Repair-deficient (dMMR);Microsatellite Instability-high (MSI-H)
干预
Neoadjuvant toripalimab plus celecoxib for 6 cycles,Neoadjuvant toripalimab monotherapy for 6 cycles,Neoadjuvant toripalimab plus celecoxib for 12 cycles,Neoadjuvant toripalimab monotherapy for 12 cycles
地点
China
申办方
Sun Yat-sen University
即将招募 Phase 2 药物其他放疗
clinicaltrials.gov NCT07527520

Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial

适用疾病
Rectal Cancer;Moderately Hypofractionated Radiotherapy;Serplulimab
干预
Moderately Hypofractionated Radiotherapy,Serplulimab,CapOx+Long-course radiotherapy
地点
China
申办方
Fudan University
即将招募 Phase 2 药物其他手术/操作
clinicaltrials.gov NCT07162714

SCRT Followed by AK112 in pMMR/MSS Mid-low Rectal Cancer

适用疾病
Rectal Cancer;Radiation;AK112
干预
radiotherapy,Ivonescimab (20mg/kg Q3W),Non-operative Management,Surgery
地点
未列出
申办方
Zhejiang Cancer Hospital
正在招募 Phase 2 药物
clinicaltrials.gov NCT06930118

The Aim of This Study is to Assess the Efficacy and Safety of Chidamide, Regorafenib in Combination With Iparomlimab and Tuvonralimab for the Treatment of Advanced Colorectal Cancer in Third-line Therapy and Subsequent Lines.

适用疾病
Advanced Colorectal Cancer in the Third-line Treatment and Beyond;pMMR/MSS Advanced Colorectal Cancer
干预
chidamide, regorafenib, and iparomlimab/tuvonralimab
地点
China
申办方
Shanghai Changzheng Hospital
正在招募 Phase 1 药物
clinicaltrials.gov NCT05005403

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

适用疾病
Non-Small Cell Lung Cancer;Head and Neck Squamous Cell Carcinoma;Micro Satellite Stable Colorectal Cancer
干预
Azirkitug,Budigalimab,Bevacizumab,Telisotuzumab Adizutecan
地点
United States,Canada,Israel,Japan 等 2 个
申办方
AbbVie
正在招募 Phase 2 药物
clinicaltrials.gov NCT06680739

Single cEll pRofiling PErsistaNce To ImmuNothErapy

适用疾病
Colorectal Cancer;Endometrial Cancer
干预
Durvalumab,Tremelimumab
地点
Spain
申办方
Vall d'Hebron Institute of Oncology
正在招募 Phase 1 药物
clinicaltrials.gov NCT06253871

A Phase 1/1b Study of IAM1363 in HER2 Cancers

适用疾病
HER2 Mutation-Related Tumors;HER2;HER2-positive Breast Cancer
干预
IAM1363
地点
United States,France,Ireland,Italy 等 4 个
申办方
Iambic Therapeutics, Inc
正在招募 Phase 2 药物
clinicaltrials.gov NCT05672524

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

适用疾病
Adenocarcinoma of the Rectum;Locally Advanced Rectal Adenocarcinoma;Rectal Adenocarcinoma
干预
Trastuzumab,Tucatinib
地点
United States
申办方
Memorial Sloan Kettering Cancer Center
即将招募 Phase 3 药物
clinicaltrials.gov NCT07483684

A Clinical Study to Evaluate Injection TQB2102 for the Treatment of Patients With HER2 IHC3+ Advanced Colorectal Cancer Who Progressed After Treatment With Oxaliplatin, Irinotecan and Fluoropyrimidine-Based Drugs

适用疾病
HER2 IHC3+ Advanced Colorectal Cancer
干预
TQB2102 Injection,Trifluridine /Tipiracil (TAS-102) tablets / Fruquintinib / Regorafenib tablets
地点
China
申办方
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
正在招募 Phase 1 药物
clinicaltrials.gov NCT07261631

Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors

适用疾病
Pancreatic Ductal Adenocarcinoma;Non-Small Cell Lung Cancer;HR+/HER2- Ductal and Lobular Breast Cancer
干预
68Ga-NNS309,177Lu-DFC413
地点
Canada,Denmark,France,Germany 等 2 个
申办方
Novartis Pharmaceuticals
正在招募 阶段未标明 药物放疗
clinicaltrials.gov NCT06349044

A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies.

适用疾病
Her-2 Negative Adenocarcinoma of the Gastro-oesophageal Junction/Gastric Adenocarcinoma;Hepatocellular Carcinoma;Biliary Tract Carcinoma
干预
Hypofractionated radiotherapy/SBRT(5-10Gy/fx,3-5 fx),Anti-PD-1 monoclonal antibody,Oxaliplatin and Capecitabine,Anti-VEGF 15mg/kg
地点
China
申办方
Zhejiang Cancer Hospital
第 1 页

Subtypes

建议拆分方向

结肠癌 colon cancer直肠癌 rectal cancer转移性结直肠癌 metastatic colorectal cancerMSI-H / dMMRMSS / pMMRKRAS / NRASBRAF V600EHER2-positiveFirst lineSecond line

Keywords

英文搜索关键词

Keyword guide

这些关键词怎么理解

术语中文意思对找临床试验有什么用
结直肠癌 / Colorectal cancer 包括结肠癌和直肠癌。不同部位、分期和分子特征会影响试验条件。 可以先用 colorectal cancer broad search,再用 colon 或 rectal 细化。
MSI-H / dMMR 提示错配修复功能异常或微卫星高度不稳定。 可以找免疫治疗、checkpoint inhibitor 等相关试验。
MSS / pMMR 微卫星稳定或错配修复功能完整,是转移性结直肠癌中常见情况。 很多试验会区分 MSI-H 和 MSS,MSS 患者常需要单独搜索。
KRAS / NRAS RAS 基因状态会影响部分靶向治疗选择和试验入组。 试验可能要求 RAS wild-type,或针对特定 RAS 突变。
BRAF V600E BRAF 的一种具体突变类型。 可以找 BRAF/MEK/EGFR 联合靶向相关试验。
HER2-positive 部分结直肠癌可能存在 HER2 扩增或高表达。 可以找 HER2 靶向药或 ADC 相关试验。
转移性结直肠癌 / metastatic colorectal cancer 癌症已经扩散到远处器官,比如肝、肺、腹膜等。 很多试验会限定 metastatic 或 unresectable 患者。

Recruitment status

常见招募状态

Recruiting正在招募,可能仍可申请参加。
Not yet recruiting尚未开始招募,可关注后续开放时间。
Active, not recruiting试验仍在进行,但通常不再招新患者。
Completed试验已经完成。
Terminated试验提前终止。
Unknown公开页面上的状态不明确或未及时更新。

Before contact

联系前准备资料

  • 病理诊断报告
  • 影像报告:CT / MRI / PET-CT
  • 既往治疗记录
  • 用药历史
  • 基因检测报告
  • 最近血液检查结果
  • 出院小结
  • 主治医生英文病情摘要,如果有
  • 护照和签证情况,如果考虑出国

Filters

搜索时重点关注

  • Recruiting / Not yet recruiting
  • Location
  • Age
  • Phase
  • Inclusion Criteria
  • Exclusion Criteria
  • Prior treatments
  • Biomarker / mutation requirements
  • ECOG performance status
  • 是否接受 international patients
  • 是否需要长期停留在试验所在地
  • 费用、保险、翻译、住宿和陪护安排

Ask your doctor

可以带去问医生的问题

  • 我的病理类型是否符合这个试验?
  • 我之前用过的药会不会影响入组?
  • 我是否需要做基因检测?
  • 这个试验是几期?主要目的是什么?
  • 参加试验会不会影响当前治疗?
  • 如果去国外参加,风险和成本大概有哪些?
  • 研究团队是否接受海外患者?
下一步提示

请将检索到的临床试验信息带给主治医生或肿瘤科医生讨论。本站不判断患者是否适合任何临床试验。