海外临床试验导航

肝癌

帮助用户按 HCC、HBV 相关、BCLC、免疫治疗、VEGF/TKI 等方向检索海外公开临床试验。

中文医学标准名
肝细胞癌
英文医学标准名
Hepatocellular Carcinoma
试验数据最后同步
2026-07-10

Synced trials

当前同步到的治疗类试验

以下记录来自公开临床试验数据库,已按招募状态、治疗目的、干预类型和癌症相关性做初步过滤。本站不判断患者是否符合入组条件,请以官方页面、医生和研究团队意见为准。

最后同步日期:2026-07-10 · 当前显示 528 条

招募状态和入组条件可能随时变化。请以官方页面、医院和研究机构信息为准,并带给主治医生或肿瘤科医生讨论。

状态
全部
试验阶段
全部
治疗类型
全部
国家/地区
全部
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT06910657

IDOV-Immune for Advanced Solid Tumors

适用疾病
Colorectal Cancer;Pancreatic Cancer;Melanoma
干预
IDOV-Immune (oncolytic vaccinia virus)
地点
United States,Australia
申办方
ViroMissile, Inc.
正在招募 Phase 4 药物
clinicaltrials.gov NCT07132515

Efficacy & Safety of Anticoagulants in Cirrhosis ± HCC

适用疾病
Cirrhosis;HCC - Hepatocellular Carcinoma;Portal Vein Thrombosis
干预
Enoxaparin, warfarrin, or apixaban
地点
Egypt
申办方
Mansoura University
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT06689540

Mts105 for Advanced Hepatocellular Carcinoma

适用疾病
Liver Cancer, Adult;Metastatic Liver Cancers;HCC - Hepatocellular Carcinoma
干预
MTS105
地点
China
申办方
Shen Lin
正在招募 Phase 1, Phase 2 生物制剂手术/操作放疗
clinicaltrials.gov NCT03942328

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

适用疾病
Stage III Hepatocellular Carcinoma AJCC v8;Stage III Intrahepatic Cholangiocarcinoma AJCC v8;Stage IV Hepatocellular Carcinoma AJCC v8
干预
Atezolizumab,Bevacizumab,External Beam Radiation Therapy,Pheresis
地点
United States
申办方
Mayo Clinic
即将招募 Phase 2 药物
clinicaltrials.gov NCT07324473

Ivarmacitinib Combined With Camrelizumab and Apatinib for Unresectable Advanced Hepatocellular Carcinoma With Acquired Resistance to Immune Checkpoint Therapy: A Single-Arm Exploratory Clinical Study

适用疾病
Hepatocellular Carcinomas;Resistance to Immunotherapy;Immunomodulation
干预
The triple-therapy strategy of Ivarmacitinib, Apatinib, and Camrelizumab
地点
China
申办方
First Affiliated Hospital of Chongqing Medical University
正在招募 Phase 1 药物
clinicaltrials.gov NCT07369505

Sapu003 in Advanced mTOR-sensitive Solid Tumors

适用疾病
Breast Cancer Metastatic;Renal Cell Carcinoma (RCC);Neuroendocrine Tumors
干预
Sapu003,Exemestane 25 MG
地点
Australia
申办方
SAPU NANO (US) LLC
即将招募 Phase 2 药物手术/操作
clinicaltrials.gov NCT07543783

Efficacy and Safety of Low-dose Bevacizumab Plus Adebrelimab Combined With Transarterial Chemoembolization Followed by Hepatic Arterial Infusion Chemotherapy (TACE-HAIC) as First-line Treatment for Unresectable Hepatocellular Carcinoma: A Single-arm Phase 2 Trial

适用疾病
Adebrelimab (SHR-1316);Bevacizumab;Hepatocellular Carcinoma (HCC)
干预
Transarterial Chemoembolization (TACE),Hepatic Arterial Infusion Chemotherapy (HAIC, FOLFOX),Adebrelimab,Low-dose Bevacizumab
地点
未列出
申办方
Third Affiliated Hospital, Sun Yat-Sen University
即将招募 Phase 2 药物其他
clinicaltrials.gov NCT07537972

Denosumab Strategy for Liver Cancer With Bone Metastases

适用疾病
Hepatocellular Carcinoma (HCC);Bone Metastases
干预
Denosumab,Sintilimab,Delayed/Rescue Bone-Modifying Strategy
地点
China
申办方
Tongji Hospital
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT06242470

A Study of MGC026 in Participants With Advanced Solid Tumors

适用疾病
Advanced Solid Tumor;Advanced Cancer;Metastatic Cancer
干预
MGC026 Dose Escalation,MGC026 Dose for Expansion
地点
United States,Australia,United Kingdom
申办方
MacroGenics
正在招募 Phase 2 药物
clinicaltrials.gov NCT05992584

Lenvatinib, Sintilimab Plus SIRT for Unresectable HCC

适用疾病
Hepatocellular Carcinoma
干预
Lenvatinib, sintilimab plus SIRT
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
正在招募 Phase 1, Phase 2 药物手术/操作
clinicaltrials.gov NCT06811116

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

适用疾病
Advanced Hepatocellular Carcinoma;Metastatic Hepatocellular Carcinoma;Stage III Hepatocellular Carcinoma AJCC v8
干预
Biospecimen Collection,Cabozantinib S-malate,Imaging Procedure,Sapanisertib
地点
United States
申办方
National Cancer Institute (NCI)
正在招募 Phase 1, Phase 2 生物制剂药物
clinicaltrials.gov NCT07500220

Dual-Target GPC3/B7-H3 CAR-NK Cells for Advanced HCC

适用疾病
Advanced Hepatocellular Carcinoma (HCC);Metastatic Liver Cancer
干预
EB-G3B7-NK dual-target CAR-NK cells,Fludarabine,Cyclophosphamide
地点
China
申办方
Beijing Biotech
即将招募 Phase 2 生物制剂药物手术/操作
clinicaltrials.gov NCT07511504

Y-90 Radioembolization, Durvalumab, Tremelimumab, and Zanzalintinib for the Treatment of Unresectable and Locally-Advanced Hepatocellular Carcinoma

适用疾病
Locally Advanced Hepatocellular Carcinoma;Stage III Hepatocellular Carcinoma AJCC v8;Stage IV Hepatocellular Carcinoma AJCC v8
干预
Angiogram,Biopsy Procedure,Biospecimen Collection,Computed Tomography
地点
United States
申办方
OHSU Knight Cancer Institute
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT05488522

SBRT With Atezo/Bev for HCC

适用疾病
Hepatocellular Carcinoma
干预
SBRT + atezolizumab and bevacizumab
地点
United States
申办方
Abramson Cancer Center at Penn Medicine
即将招募 Phase 3 手术/操作放疗
clinicaltrials.gov NCT07381660

SBRT Versus Surgical Resection for Small HCC

适用疾病
Hepatocellular Carcinoma (HCC)
干预
Stereotactic body radiotherapy (SBRT),Resection
地点
未列出
申办方
Sun Yat-sen University
正在招募 Phase 2 联合产品
clinicaltrials.gov NCT04150744

RFA Plus Carrizumab vs Carrizumab Alone for HCC

适用疾病
Tumor Immunity;Immunosuppression;Radiofrequency Ablation
干预
radiofrequency ablation
地点
China
申办方
Second Affiliated Hospital, School of Medicine, Zhejiang University
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT06914648

The Dragon PLC Trial (DRAGON-PLC)

适用疾病
Primary Liver Cancer;Hepatocellular Carcinoma (HCC);Cholangiocarcinoma
干预
Portal Vein Embolization,Hepatic Vein Embolization
地点
United States,Australia,Austria,Belgium 等 8 个
申办方
Maastricht University
正在招募 Phase 2 药物
clinicaltrials.gov NCT06789848

Ligufalimab and Cadonilimab in Advanced Liver Cancers

适用疾病
Advanced Hepatocellular Carcinoma;Refractory Hepatocellular Carcinoma;Biliary Tract Cancer
干预
Ligufalimab,Cadonilimab
地点
United States
申办方
University of Texas Southwestern Medical Center
正在招募 Phase 2 药物
clinicaltrials.gov NCT05440864

Durvalumab and Tremelimumab in Resectable HCC

适用疾病
Hepatocellular Carcinoma
干预
Tremelimumab
地点
Canada,Italy,Spain
申办方
University Health Network, Toronto
正在招募 Phase 4 手术/操作
clinicaltrials.gov NCT06717919

HOPE Against Cancer Recurrence in HCC

适用疾病
Liver Transplantation;HCC;Oncological Outcomes
干预
Hypothermic oxygenated perfusion,Conventional cold storage
地点
United States,Austria,Belgium,Czechia 等 13 个
申办方
Philipp Dutkowski
正在招募 Phase 2 药物
clinicaltrials.gov NCT04770207

Intra-tumor Injection of Drug-eluting Microspheres With Multiple Drugs

适用疾病
Hepatocellular Carcinoma;Solid Tumor, Adult
干预
Injection of drug-eluting microspheres with multiple drugs into solid tumors
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
即将招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT06400160

Clinical Trial of TB511 in Advanced Solid Tumors

适用疾病
NSCLC;Prostate Cancer;Colorectal Cancer
干预
TB511,Keytruda
地点
未列出
申办方
Twinpig Biolab, Inc.
正在招募 Phase 2 联合产品药物
clinicaltrials.gov NCT03259867

Combination of TATE and PD-1 Inhibitor in Liver Cancer

适用疾病
Hepatocellular Carcinoma;Gastric Cancer
干预
Nivolumab Injectable Product,Trans-arterial tirapazamine embolization
地点
United States
申办方
Teclison Ltd.
即将招募 阶段未标明 手术/操作
clinicaltrials.gov NCT06060847

Liver Resection and Simultaneous Sleeve Gastrectomy for MS-HCC (LIRESS)

适用疾病
Carcinoma, Hepatocellular;Metabolic Syndrome
干预
Liver resection and simultaneous sleeve gastrectomy for HCC induced by metabolic syndrome,Liver resection for HCC induced by metabolic syndrome
地点
Italy
申办方
Ospedale V. Fazzi
即将招募 Phase 2 药物
clinicaltrials.gov NCT07515469

A Prospective, Single-Arm, Exploratory Study of the Safety and Efficacy of Neoadjuvant Treatment With QL1706, an Anti-PD-1/Anti-CTLA-4 Bispecific Antibody, in Resectable Stage IB and IIA Hepatocellular Carcinoma With High Recurrence Risk

适用疾病
HCC - Hepatocellular Carcinoma;Iparomlimab and Tuvonralimab Injection;Neoadjuvant Immunotherapy
干预
Iparomlimab and Tuvonralimab
地点
未列出
申办方
Tianjin Medical University Cancer Institute and Hospital
即将招募 阶段未标明 其他放疗
clinicaltrials.gov NCT05602974

Adjuvant Stereotactic Body Radiotherapy (SBRT) for Hepatocellular Carcinoma After Hepatectomy With Narrow Margin: a Prospective, Multi-center, Randomized Controlled, Open-labelled, Phase III Study

适用疾病
Hepatocellular Carcinoma;Narrow Margin;Adjuvant Stereotactic Body Radiotherapy
干预
stereotactic body radiation therapy,regular follow-up
地点
China
申办方
Second Affiliated Hospital, School of Medicine, Zhejiang University
即将招募 Phase 2 药物手术/操作
clinicaltrials.gov NCT07584018

The DoHAICs Study Expansion Phase

适用疾病
HCC - Hepatocellular Carcinoma
干预
Donafenib,sintilimab,HAIC
地点
未列出
申办方
Tianjin Medical University Cancer Institute and Hospital
正在招募 Phase 3 药物
clinicaltrials.gov NCT05482516

Evaluating Novel Therapies in ctDNA Positive GI Cancers

适用疾病
Colon Adenocarcinoma;Rectal Adenocarcinoma;Gastric Adenocarcinoma
干预
Atezolizumab,Bevacizumab
地点
United States
申办方
Georgetown University
即将招募 阶段未标明 手术/操作
clinicaltrials.gov NCT06069947

SALT for Liver Cirrhosis With HCC

适用疾病
HCC;Liver Cirrhosis
干预
sequential adult left lateral lobe liver transplantation (SALT)
地点
未列出
申办方
RenJi Hospital
正在招募 Phase 2 手术/操作
clinicaltrials.gov NCT06707233

Y-90 SIRT for Unresectable HCC Larger Than 7cm

适用疾病
Hepatocellular Carcinoma Non-Resectable
干预
SIRT
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
正在招募 Phase 2 药物
clinicaltrials.gov NCT07317414

β-alanine in the Treatment of Advanced Hepatocellular Carcinoma

适用疾病
Hepatocellular Carcinoma
干预
Atezolizumab combined with bevacizumab combined with β- alanine,Atezolizumab combined with bevacizumab
地点
China
申办方
Peking Union Medical College Hospital
正在招募 Phase 1 药物
clinicaltrials.gov NCT06066138

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

适用疾病
Locally Advanced Alveolar Soft Part Sarcoma;Metastatic Alveolar Soft Part Sarcoma;Locally Advanced Non Small Cell Lung Cancer
干预
Atezolizumab
地点
United States
申办方
National Cancer Institute (NCI)
正在招募 Phase 2 药物
clinicaltrials.gov NCT06309485

Phase 2 Study of WGI-0301 for Advanced HCC

适用疾病
Advanced Hepatocellular Carcinoma (HCC)
干预
WGI-0301 at MTD/RP2D dose IV infusion, QW,WGI-0301 at MTD/RP2D -1 dose IV infusion, QW,Sorafenib 400 mg PO, BID continuously,Sorafenib 400 mg PO, BID
地点
China,Hong Kong
申办方
Zhejiang Haichang Biotech Co., Ltd.
正在招募 阶段未标明 药物手术/操作
clinicaltrials.gov NCT05984511

TACE Plus Atezolizumab/Bevacizumab and I-125 Seeds Brachytherapy for HCC With Branch PVTT

适用疾病
Hepatocellular Carcinoma;Hepatic Portal Vein Tumor Invasion;Tumor Thrombus
干预
I-125 Seeds Brachytherapy in PVTT,Transcatheter arterial chemoembolization,Atezolizumab plus Bevacizumab
地点
China
申办方
Third Affiliated Hospital, Sun Yat-Sen University
正在招募 Phase 1 器械药物
clinicaltrials.gov NCT05701488

SIRT With Tremelimumab and Durvalumab for Resectable HCC

适用疾病
Resectable Hepatocellular Carcinoma;Hepatocellular Carcinoma;Hepatocellular Cancer
干预
Durvalumab,Tremelimumab,SIRT
地点
United States
申办方
Jiping Wang, MD, PhD
正在招募 Phase 1, Phase 2 生物制剂
clinicaltrials.gov NCT07227012

Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.

适用疾病
Carcinoma, Hepatocellular;Hepatocellular Cancer;Hepatocellular Carcinoma
干预
PF-08634404,Ipilimumab
地点
United States,Japan,Puerto Rico,Taiwan
申办方
Pfizer
正在招募 Phase 1 生物制剂药物手术/操作
clinicaltrials.gov NCT05092373

Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax

适用疾病
Advanced Breast Carcinoma;Advanced Endometrial Carcinoma;Advanced Fallopian Tube Carcinoma
干预
Atezolizumab,Cabozantinib S-malate,Nab-paclitaxel,Tumor Treating Fields Therapy
地点
United States
申办方
M.D. Anderson Cancer Center
即将招募 Phase 1 生物制剂
clinicaltrials.gov NCT07580261

YMN-A02 for Advanced Primary Hepatocellular Carcinoma.

适用疾病
Hepatocellular Carcinoma
干预
YMN-A02 100μg,YMN-A02 250μg,YMN-A02 500μg,YMN-A02 1000μg
地点
China
申办方
West China Hospital
正在招募 Phase 1 药物
clinicaltrials.gov NCT07164313

A Study of ZW251 in Participants With Advanced Solid Tumors

适用疾病
Hepatocellular Carcinoma;Squamous Cell Non-Small Cell Lung Cancer;Germ Cell Tumor
干预
ZW251
地点
United States,Ireland,Japan,Portugal 等 2 个
申办方
Zymeworks BC Inc.
正在招募 Phase 2 联合产品药物
clinicaltrials.gov NCT06904196

Lenvatinib Plus SIRT vs Lenvatinib in TACE-Refractory HCC

适用疾病
Hepatocellular Carcinoma Non-resectable
干预
Lenvatinib plus SIRT,Lenvatinib
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
正在招募 Phase 3 手术/操作
clinicaltrials.gov NCT07322848

DEB-TACE vs cTACE in HCC After TIPS

适用疾病
Hepatocellular Carcinoma (HCC);TACE;TIPS
干预
DEB-TACE,cTACE
地点
China
申办方
First Affiliated Hospital, Sun Yat-Sen University
正在招募 Phase 1, Phase 2 生物制剂药物
clinicaltrials.gov NCT05323201

Study Of B7H3 CAR-T Cells in Treating Advanced Liver Cancer

适用疾病
Hepatocellular Carcinoma
干预
fhB7H3.CAR-Ts,Fludarabine,Cyclophosphamide
地点
China
申办方
The Affiliated Hospital of Xuzhou Medical University
即将招募 Phase 2 药物手术/操作
clinicaltrials.gov NCT07128251

A Single-Arm, Multicenter, Exploratory Clinical Study of Transarterial Chemoembolization (TACE) Combined With Iparomlimab and Tuvonralimab Injection and Bevacizumab Injection for the Treatment of Unresectable, Non-Metastatic Hepatocellular Carcinoma (HCC)

适用疾病
Hepatocellular Carcinoma (HCC);Immunotherapy;PD-1
干预
TACE treatment,Iparomlimab and Tuvonralimab Injection (QL1706),Bevacizumab
地点
未列出
申办方
Anhui Provincial Hospital
即将招募 Phase 2 药物手术/操作
clinicaltrials.gov NCT07131501

A Single-Arm, Multicenter, Exploratory Clinical Study of TACE Combined With Iparomlimab and Tuvonralimab Injection (QL1706) and Lenvatinib for Perioperative Treatment of Resectable Hepatocellular Carcinoma

适用疾病
Hepatocellular Carcinoma;Immunotherapy;Preoperative
干预
Radical surgery,TACE treatment,Iparomlimab and Tuvonralimab Injection (QL1706),Lenvatinib
地点
China
申办方
The First Affiliated Hospital with Nanjing Medical University
正在招募 Phase 2 药物
clinicaltrials.gov NCT05412589

mFOLFOX7 Plus Camrelizumab and Apatinib for Advanced HCC

适用疾病
Stage III Hepatocellular Cancer (CNLC Staging)
干预
mFOLFOX7+Camrelizumab+Apatinib
地点
China
申办方
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
即将招募 Phase 2 药物
clinicaltrials.gov NCT07314372

FAD Subtype-Guided Combination Therapy for Unresectable Hepatocellular Carcinoma

适用疾病
Unresectable Hepatocellular Carcinoma (HCC);Hepatocellular Carcinoma (HCC);Liver Cancer Adult
干预
Camrelizumab Plus Apatinib,TACE Plus Camrelizumab and Apatinib
地点
China
申办方
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
即将招募 Phase 4 手术/操作
clinicaltrials.gov NCT02785380

Laparoscopic Surgery VS RFA for Recurrent HCC

适用疾病
Hepatocellular Carcinoma
干预
laparoscopic surgery(LS),RFA
地点
未列出
申办方
Sun Yat-sen University
正在招募 Phase 2 药物
clinicaltrials.gov NCT07489976

IIT2025-03-YANG-LIFT-HCC

适用疾病
Hepato Cellular Carcinoma
干预
STRIDE Regimen (Tremelimumab 300 mg AND Durvalumab 1500 mg) combined with LRT (TACE, TARE, or RFA)
地点
United States
申办方
Ju Dong Yang
正在招募 Phase 1 药物放疗
clinicaltrials.gov NCT05096715

Atezolizumab+Bevacizumab+SBRT in Unresectable HCC

适用疾病
Unresectable Hepatocellular Carcinoma
干预
Atezolizumab,Bevacizumab,Stereotactic body radiation therapy (SBRT)
地点
United States
申办方
Massachusetts General Hospital
即将招募 阶段未标明 手术/操作
clinicaltrials.gov NCT07690683

Patients With Hepatocellular Carcinoma (HCC)

适用疾病
Hepatocellular Carcinoma;Hepatocellular Cancer;Liver Diseases
干预
Fecal microbiota transplantation performed via colonoscopy.,Simulated Colonoscopy With Placebo Capsules in Addition to Standard Treatment
地点
Italy
申办方
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
正在招募 Phase 1 药物
clinicaltrials.gov NCT07348211

First in Human Study of SIM0610 in Solid Tumors

适用疾病
Advanced Solid Tumours;Non-Small Cell Lung Cancer;Colorectal Cancer
干预
SIM0610 for Injection,SIM0610 for Injection
地点
China
申办方
Jiangsu Simcere Pharmaceutical Co., Ltd.
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05824975

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

适用疾病
Advanced Solid Tumor;Metastatic Solid Tumor;Soft Tissue Sarcoma (STS)
干预
GI-102 subcutaneous (SC),GI-102,doxorubicin,paclitaxel
地点
United States,South Korea
申办方
GI Innovation, Inc.
正在招募 阶段未标明 手术/操作
clinicaltrials.gov NCT05994859

SIRT for Potentially Resectable HCC

适用疾病
Hepatocellular Carcinoma
干预
SIRT
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
正在招募 Phase 1, Phase 2 药物手术/操作
clinicaltrials.gov NCT07042919

Zanzalintinib in Second Line and Beyond for the Treatment of Advanced Liver Cancer

适用疾病
Advanced Hepatocellular Carcinoma;Cirrhosis;Stage III Hepatocellular Carcinoma AJCC v8
干预
Biospecimen Collection,Computed Tomography,Magnetic Resonance Imaging,Multigated Acquisition Scan
地点
United States
申办方
Devalingam Mahalingam
即将招募 EARLY / Phase 1 生物制剂
clinicaltrials.gov NCT07657416

NK521 in the Treatment of Advanced Solid Tumors

适用疾病
Hepatocellular Carcinoma (HCC);Ovarian Cancer;Malignant Ascites
干预
NK521 Cell Injection,NK521 Cell Injection
地点
China
申办方
Base Therapeutics (Shanghai) Co., Ltd.
正在招募 阶段未标明 药物放疗
clinicaltrials.gov NCT06349044

A Randomized, Multicenter Phase II Basket Study of Hypofractionated Radiotherapy/Stereotactic Body Radiotherapy Followed by Immunotherapy-Based Systemic Therapy +/- L. Rhamnosus M9 for the First-Line Treatment of Advanced Digestive System Malignancies.

适用疾病
Her-2 Negative Adenocarcinoma of the Gastro-oesophageal Junction/Gastric Adenocarcinoma;Hepatocellular Carcinoma;Biliary Tract Carcinoma
干预
Hypofractionated radiotherapy/SBRT(5-10Gy/fx,3-5 fx),Anti-PD-1 monoclonal antibody,Oxaliplatin and Capecitabine,Anti-VEGF 15mg/kg
地点
China
申办方
Zhejiang Cancer Hospital
正在招募 Phase 2 药物其他
clinicaltrials.gov NCT06762782

Clinical Study on the Effectiveness and Safety of Lenvatinib As Adjuvant Treatment for Patients with High-risk Recurrence of Hepatocellular Carcinoma After Surgery

适用疾病
Hepatocellular Carcinoma (HCC);Adjuvant Therapy in Patients with Hepatocellular Carcinoma (HCC) At High Risk of Recurrence After Curative Resection or Ablation
干预
Postoperative adjuvant lenvatinib,Supportive care measures
地点
China
申办方
The First Affiliated Hospital with Nanjing Medical University
正在招募 Phase 2 生物制剂药物其他
clinicaltrials.gov NCT07219459

Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

适用疾病
Unresectable or Metastatic Hepatocellular Carcinoma;Child-Pugh A Hepatocellular Carcinoma;Failure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound
干预
Visugromab RDE (recommended dose for expansion),Nivolumab,Lenvatinib,Placebo Saline Infusion
地点
United States,Germany,Italy,Spain
申办方
CatalYm GmbH
正在招募 Phase 1, Phase 2 药物
clinicaltrials.gov NCT05919264

FOG-001 in Locally Advanced or Metastatic Solid Tumors

适用疾病
Cancer;Colorectal Cancer;Solid Tumor
干预
FOG-001,mFOLFOX-6,Nivolumab,Trifluridine/tipiracil
地点
United States,Australia
申办方
Parabilis Medicines, Inc.
正在招募 Phase 2 药物
clinicaltrials.gov NCT06397235

DEB-TACE+RALOX-HAIC vs DEB-TACE for Large HCC

适用疾病
Hepatocellular Carcinoma Non-resectable
干预
DEB-TACE+HAIC,DEB-TACE
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
正在招募 Phase 1 生物制剂
clinicaltrials.gov NCT04147078

Personalized DC Vaccine for Postoperative Cancer

适用疾病
Gastric Cancer;Hepatocellular Carcinoma;Non-Small-Cell Lung Cancer
干预
DC vaccine subcutaneous administration
地点
China
申办方
Sichuan University
正在招募 Phase 1 药物
clinicaltrials.gov NCT05208762

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

适用疾病
Carcinoma, Non-Small-Cell Lung;Squamous Cell Carcinoma of the Head and Neck;Esophageal Squamous Cell Carcinoma
干预
PF-08046054,pembrolizumab
地点
United States,Belgium,Canada,China 等 7 个
申办方
Seagen, a wholly owned subsidiary of Pfizer
正在招募 Phase 3 药物
clinicaltrials.gov NCT05608200

Lenvatinib+Sintilimab+TACE vs. Lenvatinib+TACE for Advanced HCC

适用疾病
Hepatocellular Carcinoma Non-resectable
干预
Lenvatinib, sintilimab plus TACE,Lenvatinib plus TACE
地点
China
申办方
Second Affiliated Hospital of Guangzhou Medical University
即将招募 Phase 1 生物制剂
clinicaltrials.gov NCT07558200

Phase Ia/Ib Study of FXB0871 Monotherapy in Locally Advanced/Metastatic Solid Tumors

适用疾病
Solid Tumors;Non-Small Cell Lung Cancer;Hepatocellular Carcinoma
干预
Intervention1:FXB0871,Intervention2:FXB0871,Intervention3:FXB0871,Intervention4:FXB0871
地点
China
申办方
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
正在招募 Phase 2 药物手术/操作
clinicaltrials.gov NCT07327788

QL1706 in Combination With Bevacizumab and RALOX HAIC for Hepatocellular Carcinoma With Vp3/4 PVTT

适用疾病
Hepatecellular Carcinoma;RALOX-HAIC(Hepatic Arterial Infusion Chemotherapy With Raltitrexed and Oxaliplatin;Bevacizumab
干预
Iparomlimab and Tuvonralimab Injection (QL1706),Bevacizumab,Hepatic Arterial Infusion Chemotherapy with Raltitrexed and Oxaliplatin (RALOX-HAIC)
地点
China
申办方
Nanfang Hospital, Southern Medical University
正在招募 Phase 3 药物手术/操作放疗
clinicaltrials.gov NCT07186621

Adjuvant Radiotherapy of Sintilimab Versus TACE for HCC

适用疾病
Hepatocellular Carcinoma (HCC);Radiotherapy, Adjuvant;Immune Checkpoint Inhibitor
干预
Sintilimab,radiotherapy,TACE
地点
China
申办方
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
正在招募 Phase 1 基因治疗
clinicaltrials.gov NCT07364357

A Phase I Study of CREPT-618 in Locally Advanced HCC

适用疾病
Hepatocellular Carcinoma (HCC)
干预
gene therapy
地点
China
申办方
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
即将招募 阶段未标明 药物
clinicaltrials.gov NCT07253220

TAF Monotherapy Versus ETV Combined With TAF on the Efficacy and Prognosis of Immunotherapy for Hepatitis B-Related Hepatocellular Carcinoma

适用疾病
Hepatitis B;Hepatocellular Carcinoma (HCC)
干预
The arm will receive combination therapy (entecavir 0.5 mg once daily plus TAF 25 mg once daily); after HBV DNA becomes undetectable, the combination group will switch to TAF monotherapy.,TAF monotherapy
地点
未列出
申办方
Sun Yat-sen University
第 1 页

Subtypes

建议拆分方向

hepatocellular carcinoma / HCCadvanced liver cancerunresectable HCCHBV-related HCCBCLC stageimmunotherapyVEGFTKI

Keywords

英文搜索关键词

Keyword guide

这些关键词怎么理解

术语中文意思对找临床试验有什么用
肝细胞癌 / HCC 最常见的原发性肝癌类型。 海外试验常用 hepatocellular carcinoma 或 HCC,而不只写 liver cancer。
不可切除 / Unresectable 通常指无法通过手术完整切除,具体由医生评估。 很多系统治疗试验会限定 unresectable HCC。
HBV-related HCC 和乙肝相关的肝细胞癌。 部分试验会关注 HBV 状态、抗病毒治疗或肝功能要求。
BCLC stage 肝癌常用分期体系之一。 试验可能会限定 BCLC B 或 C 等阶段。
Immunotherapy 免疫治疗方向,例如 PD-1、PD-L1、CTLA-4 等。 可以找免疫联合 VEGF/TKI 或二线免疫治疗试验。
Child-Pugh 评估肝功能状态的评分。 很多肝癌试验会要求 Child-Pugh A 等条件。

Recruitment status

常见招募状态

Recruiting正在招募,可能仍可申请参加。
Not yet recruiting尚未开始招募,可关注后续开放时间。
Active, not recruiting试验仍在进行,但通常不再招新患者。
Completed试验已经完成。
Terminated试验提前终止。
Unknown公开页面上的状态不明确或未及时更新。

Before contact

联系前准备资料

  • 病理诊断报告
  • 影像报告:CT / MRI / PET-CT
  • 既往治疗记录
  • 用药历史
  • 基因检测报告
  • 最近血液检查结果
  • 出院小结
  • 主治医生英文病情摘要,如果有
  • 护照和签证情况,如果考虑出国

Filters

搜索时重点关注

  • Recruiting / Not yet recruiting
  • Location
  • Age
  • Phase
  • Inclusion Criteria
  • Exclusion Criteria
  • Prior treatments
  • Biomarker / mutation requirements
  • ECOG performance status
  • 是否接受 international patients
  • 是否需要长期停留在试验所在地
  • 费用、保险、翻译、住宿和陪护安排

Ask your doctor

可以带去问医生的问题

  • 我的病理类型是否符合这个试验?
  • 我之前用过的药会不会影响入组?
  • 我是否需要做基因检测?
  • 这个试验是几期?主要目的是什么?
  • 参加试验会不会影响当前治疗?
  • 如果去国外参加,风险和成本大概有哪些?
  • 研究团队是否接受海外患者?
下一步提示

请将检索到的临床试验信息带给主治医生或肿瘤科医生讨论。本站不判断患者是否适合任何临床试验。